A novel marker, ARM58, confers antimony resistance to Leishmania spp.
نویسندگان
چکیده
منابع مشابه
A novel marker, ARM58, confers antimony resistance to Leishmania spp.☆
Protozoa of the Leishmania genus cause a variety of disease forms that rank at the top of the list of neglected tropical diseases. Anti-leishmanial drugs based on pentavalent antimony have been the mainstay of therapy for over 60 years and resistance against them is increasingly encountered in the field. The biochemical basis for this is poorly understood and likely diverse. No stringent correl...
متن کاملReduced Antimony Accumulation in ARM 58 - Overexpressing 1 Leishmania infantum 2 Running title : ARM 58 antimony resistance marker
17 Antimony-based drugs are still the mainstay of chemotherapy against Leishmania infections in 18 many endemic countries. Efficacy of antimonials has been compromised by increasing numbers of 19 resistant infections, the basis of which is not fully understood and likely involves multiple factors. 20 By using a functional cloning strategy he have recently identified a novel antimony resistance ...
متن کاملLeishmania major LmACR2 is a pentavalent antimony reductase that confers sensitivity to the drug pentostam.
Arsenicals and antimonials are first line drugs for the treatment of trypanosomal and leishmanial diseases. To create the active form of the drug, Sb(V) must be reduced to Sb(III). Because arsenic and antimony are related metalloids, and arsenical resistant Leishmania strains are frequently cross-resistant to antimonials, we considered the possibility that Sb(V) is reduced by a leishmanial As(V...
متن کاملMolecular characterization of the MRPA transporter and antimony uptake in four New World Leishmania spp. susceptible and resistant to antimony☆
ATP-binding cassette (ABC) transporters have been associated with drug resistance in various diseases. The MRPA gene, a transporter of ABCC subfamily, is involved in the resistance by sequestering metal-thiol conjugates in intracellular vesicles of Leishmania parasite. In this study, we performed the molecular characterization of the MRPA transporter, analysis of P-glycoprotein (Pgp) and aquagl...
متن کاملInhibition of ABC transporters abolishes antimony resistance in Leishmania Infection.
The emergence of antimony (Sb) resistance has jeopardized the treatment of visceral leishmaniasis in various countries. Previous studies have considered the part played by leishmanial parasites in antimony resistance, but the involvement of host factors in the clinical scenario remained to be investigated. Here we show that unlike infection with Sb-sensitive (Sbs) Leishmania donovani, infection...
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ژورنال
عنوان ژورنال: International Journal for Parasitology: Drugs and Drug Resistance
سال: 2014
ISSN: 2211-3207
DOI: 10.1016/j.ijpddr.2013.11.004